CANNABIDIOL & PROSTATE CANCER

HOW DOES IT WORK?


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Manju Sharma and her team investigated the anti tumor and anti-inflammatory activities of cannabidiol (CBD) in human prostate cancer cell lines. Assessed whether there is any advantage in using cannabis extracts enriched in cannabidiol and low in THC. Their results, obtained in a panel of prostate cancer cell lines clearly indicate that cannabidiol is a potent inhibitor of cancer cell growth, with significantly lower potency in non-cancer cells. overall findings support the concept that cannabidiol, which lacks psychotropic activity, may possess anti-inflammatory property and downregulates both cannabinoid receptors. High CBD cannabis extracts are cytotoxic to androgen- responsive LNCaP cells and may effectively inhibit spheroid formation in cancer stem cells. This activity may contribute to its anticancer and chemosensitizing effect against prostate cancer. Therefore, they concluded that cannabidiol and other non-habit forming cannabinoids could be used as novel therapeutic agents for the treatment of prostate cancer. (1) July 2014


Animal and human studies have suggested that cannabidiol (CBD) may possess anxiolytic properties, but how these effects are mediated centrally is unknown. A study by José Alexandre Souza Crippa et al published in 2004 took healthy male volunteers, randomly divided into two groups of five subjects. Each subject was studied on two occasions, 1 week apart. In the first session, subjects were given an oral dose of CBD (400 mg) or placebo, in a double-blind procedure. SPECT images were acquired 90 min after drug ingestion. The Visual Analogue Mood Scale was applied to assess subjective states. In the second session, the same procedure was performed using the drug that had not been administered in the previous session, comparisons were performed using statistical parametric mapping. These results suggest that CBD has anxiolytic properties and that these effects are mediated by an action on limbic and paralimbic brain areas. CBD significantly decreased subjective anxiety and increased mental sedation, while placebo did not induce significant changes. (2) 2014







REFERENCES TO PRIMARY LITERATURE

  1. IN VITRO ANTICANCER ACTIVITY OF PLANT-DERIVED CANNABIDIOL ON PROSTATE CANCER CELL LINES. HTTPS://WWW.RESEARCHGATE.NET/PUBLICATION/266317566_IN_VITRO_ANTICANCER_ACTIVITY_OF_PLANT-DERIVED_CANNABIDIOL_ON_PROSTATE_CANCER_CELL_LINES

  2. EFFECTS OF CANNABIDIOL (CBD) ON REGIONAL CEREBRAL BLOOD FLOW.  HTTPS://WWW.SEMANTICSCHOLAR.ORG/PAPER/EFFECTS-OF-CANNABIDIOL-(CBD)-ON-REGIONAL-CEREBRAL-CRIPPA-ZUARDI/128EFABADA8288561B7D452D597AF22B0ECF4ED4

ADDITIONAL READING

  1. 128EFABADA8288561B7D452D597AF22B0ECF4ED4

  2. APPRAISING THE “ENTOURAGE EFFECT”: ANTITUMOR ACTION OF A PURE CANNABINOID VERSUS A BOTANICAL DRUG PREPARATION IN PRECLINICAL MODELS OF BREAST CANCER HTTPS://WWW.SCIENCEDIRECT.COM/SCIENCE/ARTICLE/ABS/PII/S0006295218302387

  3. ANTITUMOR ACTIVITY OF PLANT CANNABINOIDS WITH EMPHASIS ON THE EFFECT OF CANNABIDIOL ON HUMAN BREAST CARCINOMA. HTTPS://WWW.NCBI.NLM.NIH.GOV/PUBMED/20859676 PATHWAYS MEDIATING THE EFFECTS OF CANNABIDIOL ON THE REDUCTION OF BREAST CANCER CELL PROLIFERATION

  4. HTTPS://WWW.SCIENCEDIRECT.COM/SCIENCE/ARTICLE/ABS/PII/S0006295218302387

  5. ANTITUMOR EFFECTS OF CANNABIDIOL, A NONPSYCHOACTIVE CANNABINOID, ON HUMAN GLIOMA CELL LINES. HTTPS://WWW.NCBI.NLM.NIH.GOV/PUBMED/14617682



GLOSSARY

Anxiolytic

Also, anti panic or anti anxiety agent - is a medication or other intervention that inhibits anxiety.

Apoptosis

The death of cells which occurs as a normal and controlled part of an organism's growth or development.

Cell proliferation

The process that results in an increase of the number of cells and is defined by the balance between cell divisions and cell loss through cell death or differentiation.

CBD

Cannabidiol (CBD) is a naturally occurring compound found in the resinous flower of cannabis.

CBG

Cannabigerol (CBG) is a non-psychoactive cannabinoid that plays an important role in the biochemistry of the cannabis plant. CBG acts as a chemical precursor to other cannabinoids such as THC and CBD. CBG reacts with the cannabinoid receptors in the brain. CBG, however, acts as a buffer to the psycho activity of THC by working to alleviate the paranoia sometimes caused by higher levels of THC.

Non psychotropic

Any drug capable of affecting the mind, emotions, and behavior is psychotropic

adjective- affecting mental activity, behavior, or perception, as a mood-altering drug.

KINASE

An enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates.

VISUAL ANALOGUE MOOD SCALE

Is a reliable and valid measure of eight specific mood states: Afraid, Confused, Sad, Angry, Energetic, Tired, Happy, and Tense

SPECT IMAGES

A single-photon emission computerized tomography (SPECT) scan lets your doctor analyze the function of some of your internal organs. A SPECT scan is a type of nuclear imaging test, which means it uses a radioactive substance and a special camera to create 3-D pictures.